Background | Setting | Direct variational perspective | The need for an R package | Adoptr's structure | Examples | Standard case | Optimization under uncertainty | Utility maximization and composite scores | Conditional power constraint | Keeping design parameters fixed | Validation concept | Future work | Acknowledgments | References

Binary endpoints | Asymptotic distribution of the test statistic | adoptr and binomial endpoints | Implementation details | Example | Time-to-event endpoints | Survival analysis and adaptive designs | Notation | Dependency issues and solutions | Solution 1: Independent increments | Solution 2: Left truncation at the second stage

Two-stage designs for clinical trials | Example | Define hypotheses and data-generating mechanism | Specify optimization problem | Variations

Functional Composition

(Un)conditional Scores in adoptr | Conditional Constraints

Discrete priors | Continuous priors | Conditioning